Olivia Petrillo

Mar 2022 - Present

Sr. Research Associate, Bioinformatics

Mar 2023 - Present

Research Associate II, Bioinformatics

Mar 2022 - Mar 2023

Process transcriptomic and whole exome sequencing data to support GRANITE Phase 2/3 trial for personalized neoantigen vaccines
Develop and maintain bioinformatics pipelines with Nextflow to process Illumina sequencing data in a GMP-regulated environment
Conduct ad-hoc analysis of both internal and external next-generation sequencing (NGS) data to support research projects and process development efforts
Maintain and revise technical documentation, standard operating procedures, software specifications, and qualification protocols through change controls
Collaborate closely with NGS, QA, Cloud Engineering, Clinical, and Manufacturing teams

Jounce Therapeutics, Cambridge, MA

Jul 2021 - Dec 2021

Acquired by Concentra Biosciences Mar 2023

Bioinformatics Co-op

Analyzed imputed single-cell RNA-seq data with Seurat to annotate and verify cell subpopulations from the whole tumor microenvironment
Characterized cell differentiation trajectories based on transcriptional dynamics and pseudotemporally ordered cells with Monocle3 to investigate gene expression patterns during differentiation
Supported early-discovery programs by analyzing the differences between gene expression of myeloid targets as a function of pseudotime
Clearly communicated and presented applicable analysis within team subgroups as well as to the whole company

Gritstone bio, Boston, MA

Jul 2020 - Feb 2021

Bioinformatics Co-op

Processed and analyzed single-cell RNA-seq data using the 10x Genomics Chromium technology and Illumina HiSeq, MiSeq, and NovaSeq platforms
Integrated multi-modal data to profile cell populations within a tumor
Maintained research pipelines for sequencing analysis, generated workflows to automate processes including sequence alignment, mapping, read quantification, normalization, and variant calling
Modeled intratumor heterogeneity of single-cell populations using statistical distributions to characterize dropouts and true gene expression
Created user-friendly program to assist wet lab collaborators with standardization and analysis of cytokine response data
Supported external company collaboration with bluebird bio (now 2seventy bio), identifying tumor-specific targets for cell therapy
Developed internal quality control metrics for data cleanup and delivery

PowerAdvocate, Boston, MA

Jul 2019 - Dec 2019

Now part of Wood Mackenzie

Software Development Co-op

Redesigned and delivered a highly used feature of a client-facing web application utilizing React
Acted as lead from beginning to end on a full-stack feature, extensively pairing with other developers
Produced high-quality code through unit and functional tests, cross-team code review, and automated browser testing using Selenium
Communicated closely with product owners and negotiated business requirements for projects
Worked in an Agile environment collaborating with a team of approximately 30 developers and IT/DevOps
Presented 4 months of work for a recently delivered feature during a company-wide technology review